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Beilstein J. Org. Chem. 2009, 5, No. 5, doi:10.3762/bjoc.5.5
Graphical Abstract
Figure 1: Proposed reaction mechanism for the formation of Cα-tetrasubstituted tetrahydrofuran α-amino acids.
Scheme 1: Cyclisation reaction forming the tetrahydrofuran amino acid (TAA).
Figure 2: Structure of compound 15 in the solid state determined by X-ray analysis [21].